Shear-induced integrin signaling in platelet phosphatidylserine exposure, microvesicle release, and coagulation

It is currently unclear why agonist-stimulated platelets require shear force to efficiently externalize the procoagulant phospholipid phosphatidylserine (PS) and release PS-exposed microvesicles (MVs). We reveal that integrin outside-in signaling is an important mechanism for this requirement. PS ex...

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Bibliographische Detailangaben
Veröffentlicht in:Blood
Hauptverfasser: Pang, Aiming, Cui, Yujie, Chen, Yunfeng, Cheng, Ni, Delaney, M. Keegan, Gu, Minyi, Stojanovic-Terpo, Aleksandra, Zhu, Cheng, Du, Xiaoping
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2018
Schlagworte:
Thrombosis and Hemostasis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6073322/
https://ncbi.nlm.nih.gov/pubmed/29853537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-05-785253
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