Agonist-induced platelet procoagulant activity requires shear and a Rac1-dependent signaling mechanism

Activated platelets facilitate blood coagulation by exposing phosphatidylserine (PS) and releasing microvesicles (MVs). However, the potent physiological agonists thrombin and collagen poorly induce PS exposure when a single agonist is used. To obtain a greater procoagulant response, thrombin is com...

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Hlavní autoři: Delaney, Michael Keegan, Liu, Junling, Kim, Kyungho, Shen, Bo, Stojanovic-Terpo, Aleksandra, Zheng, Yi, Cho, Jaehyung, Du, Xiaoping
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2014
Témata:
Thrombosis and Hemostasis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4168351/
https://ncbi.nlm.nih.gov/pubmed/25079357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-03-560821
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