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Agonist-induced platelet procoagulant activity requires shear and a Rac1-dependent signaling mechanism
Activated platelets facilitate blood coagulation by exposing phosphatidylserine (PS) and releasing microvesicles (MVs). However, the potent physiological agonists thrombin and collagen poorly induce PS exposure when a single agonist is used. To obtain a greater procoagulant response, thrombin is com...
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| Main Authors: | , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society of Hematology
2014
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4168351/ https://ncbi.nlm.nih.gov/pubmed/25079357 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-03-560821 |
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