Combined c-Met/Trk inhibition overcomes resistance to CDK4/6 inhibitors in Glioblastoma

Glioblastoma (GBM) is the most common primary brain malignancy and carries an extremely poor prognosis. Recent molecular studies revealed the CDK4/6-Rb-E2F axis and receptor tyrosine kinase (RTK) signaling to be deregulated in most GBM, creating an opportunity to develop more effective therapies by...

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Pubblicato in:Cancer Res
Autori principali: Olmez, Inan, Zhang, Ying, Manigat, Laryssa, Benamar, Mouadh, Brenneman, Breanna, Nakano, Ichiro, Godlewski, Jakub, Bronisz, Agnieszka, Lee, Jeongwu, Abbas, Tarek, Abounader, Roger, Purow, Benjamin
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072607/
https://ncbi.nlm.nih.gov/pubmed/29844123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-3124
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