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Chemical probes of Skp2-mediated p27 ubiquitylation and degradation

Skp2 is a member of the F-box family of proteins that serve as substrate-specific adaptors in Skp1–CUL1–ROC1–F-box (SCF) E3 ubiquitin ligases. Skp2 (Fbxl1) directly binds to the tumor suppressor p27 in the context of the SCF(Skp2) E3 ubiquitin ligase to ubiquitylate and target-phosphorylated p27 for...

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Veröffentlicht in:Medchemcomm
Hauptverfasser: Lough, Lea, Sherman, Dan, Ni, Eric, Young, Lauren M., Hao, Bing, Cardozo, Timothy
Format: Artigo
Sprache:Inglês
Veröffentlicht: Royal Society of Chemistry 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072517/
https://ncbi.nlm.nih.gov/pubmed/30108998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00140e
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