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Chemical probes of Skp2-mediated p27 ubiquitylation and degradation
Skp2 is a member of the F-box family of proteins that serve as substrate-specific adaptors in Skp1–CUL1–ROC1–F-box (SCF) E3 ubiquitin ligases. Skp2 (Fbxl1) directly binds to the tumor suppressor p27 in the context of the SCF(Skp2) E3 ubiquitin ligase to ubiquitylate and target-phosphorylated p27 for...
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| Veröffentlicht in: | Medchemcomm |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Royal Society of Chemistry
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6072517/ https://ncbi.nlm.nih.gov/pubmed/30108998 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00140e |
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