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Specific Small Molecule Inhibitors of Skp2-Mediated p27 Degradation
In the ubiquitin proteasome system, the E3 ligase SCF-Skp2 and its accessory protein Cks1 promote proliferation largely by inducing the degradation of the CDK inhibitor p27. Overexpression of Skp2 in human cancers correlates with poor prognosis, and deregulation of SCF-Skp2-Cks1 promotes tumorigenes...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3530153/ https://ncbi.nlm.nih.gov/pubmed/23261596 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2012.09.015 |
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