Llwytho...

Specific Small Molecule Inhibitors of Skp2-Mediated p27 Degradation

In the ubiquitin proteasome system, the E3 ligase SCF-Skp2 and its accessory protein Cks1 promote proliferation largely by inducing the degradation of the CDK inhibitor p27. Overexpression of Skp2 in human cancers correlates with poor prognosis, and deregulation of SCF-Skp2-Cks1 promotes tumorigenes...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Wu, Lily, Grigoryan, Arsen V., Li, Yunfeng, Hao, Bing, Pagano, Michele, Cardozo, Timothy
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3530153/
https://ncbi.nlm.nih.gov/pubmed/23261596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2012.09.015
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