Inhibitors of SCF-Skp2/Cks1 E3 Ligase Block Estrogen-Induced Growth Stimulation and Degradation of Nuclear p27(kip1): Therapeutic Potential for Endometrial Cancer

In many human cancers, the tumor suppressor, p27(kip1) (p27), a cyclin-dependent kinase inhibitor critical to cell cycle arrest, undergoes perpetual ubiquitin-mediated proteasomal degradation by the E3 ligase complex SCF-Skp2/Cks1 and/or cytoplasmic mislocalization. Lack of nuclear p27 causes aberra...

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Bibliografiske detaljer
Main Authors: Pavlides, Savvas C., Huang, Kuang-Tzu, Reid, Dylan A., Wu, Lily, Blank, Stephanie V., Mittal, Khushbakhat, Guo, Lankai, Rothenberg, Eli, Rueda, Bo, Cardozo, Timothy, Gold, Leslie I.
Format: Artigo
Sprog:Inglês
Udgivet: Endocrine Society 2013
Fag:
Cancer-Oncogenes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3800755/
https://ncbi.nlm.nih.gov/pubmed/24035998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2013-1757
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