TGF-β activates APC through Cdh1 binding for Cks1 and Skp2 proteasomal destruction stabilizing p27kip1 for normal endometrial growth

We previously reported that aberrant TGF-β/Smad2/3 signaling in endometrial cancer (ECA) leads to continuous ubiquitylation of p27(kip1)(p27) by the E3 ligase SCF-Skp2/Cks1 causing its degradation, as a putative mechanism involved in the pathogenesis of this cancer. In contrast, normal intact TGF-β...

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Detalhes bibliográficos
Publicado no:Cell Cycle
Main Authors: Pavlides, Savvas C., Lecanda, Jon, Daubriac, Julien, Pandya, Unnati M., Gama, Patricia, Blank, Stephanie, Mittal, Khushbakhat, Shukla, Pratibha, Gold, Leslie I.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889277/
https://ncbi.nlm.nih.gov/pubmed/26963853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2016.1150393
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