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High-Throughput Screening AlphaScreen Assay for Identification of Small-Molecule Inhibitors of Ubiquitin E3 Ligase SCF(Skp2-Cks1)

Decreased levels of cell cycle inhibitor p27(Kip1) due to excessive degradation occur in a variety of aggressive human tumors. Since reduced p27(Kip1) expression has been associated with a poor prognosis in many human cancers and resistance to certain antitumor therapies, elevation of p27(Kip1) expr...

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Bibliografiske detaljer
Main Authors: Ungermannova, Dana, Lee, Junglim, Zhang, Gan, Dallmann, H. Garry, McHenry, Charles S., Liu, Xuedong
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4168015/
https://ncbi.nlm.nih.gov/pubmed/23589337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057113485789
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