SKP2 targeted inhibition suppresses human uveal melanoma progression by blocking ubiquitylation of p27

Background: SKP2 is considered an oncogene involved in various malignancies. SKP2 protein is a critical subunit of the SKP1-CUL1-F-box (SCF) E3 ligase complex which affects the cell cycle profoundly by specifically recognizing cell cycle regulators and mediating their ubiquitylation and proteasomal...

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Bibliografiske detaljer
Udgivet i:Onco Targets Ther
Main Authors: Zhao, Hongbo, Pan, Hui, Wang, Huixue, Chai, Peiwei, Ge, Shengfang, Jia, Renbing, Fan, Xianqun
Format: Artigo
Sprog:Inglês
Udgivet: Dove 2019
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6549483/
https://ncbi.nlm.nih.gov/pubmed/31213847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S203888
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