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SKP2 targeted inhibition suppresses human uveal melanoma progression by blocking ubiquitylation of p27
Background: SKP2 is considered an oncogene involved in various malignancies. SKP2 protein is a critical subunit of the SKP1-CUL1-F-box (SCF) E3 ligase complex which affects the cell cycle profoundly by specifically recognizing cell cycle regulators and mediating their ubiquitylation and proteasomal...
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| Publicado en: | Onco Targets Ther |
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| Autores principales: | , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Dove
2019
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6549483/ https://ncbi.nlm.nih.gov/pubmed/31213847 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S203888 |
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