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Small molecules inhibiting Keap1–Nrf2 protein–protein interactions: a novel approach to activate Nrf2 function

Oxidative stress is well recognized to contribute to the cause of a wide range of diseases, such as cancer, diabetes, Alzheimer's disease, arteriosclerosis, and inflammation. The Keap1–Nrf2–ARE pathway plays a critical regulatory role and can protect cells from oxidative stress through activati...

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Publicado en:Medchemcomm
Main Authors: Zhuang, Chunlin, Wu, Zhongli, Xing, Chengguo, Miao, Zhenyuan
Formato: Artigo
Idioma:Inglês
Publicado: Royal Society of Chemistry 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072482/
https://ncbi.nlm.nih.gov/pubmed/30108745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6md00500d
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