Combined Peptide and Small-Molecule Approach toward Nonacidic THIQ Inhibitors of the KEAP1/NRF2 Interaction

[Image: see text] The NRF2-ARE pathway is an intrinsic mechanism of defense against oxidative stress. Inhibition of the interaction between NRF2 and its main negative regulator KEAP1 is an attractive strategy toward neuroprotective agents. We report here the identification of nonacidic tetrahydroiso...

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Detaylı Bibliyografya
Yayımlandı:ACS Med Chem Lett
Asıl Yazarlar: Ontoria, Jesus M., Biancofiore, Ilaria, Fezzardi, Paola, Ferrigno, Federica, Torrente, Esther, Colarusso, Stefania, Bianchi, Elisabetta, Andreini, Matteo, Patsilinakos, Alexandros, Kempf, Georg, Augustin, Martin, Steinbacher, Stefan, Summa, Vincenzo, Pacifici, Robert, Muñoz-Sanjuan, Ignacio, Park, Larry, Bresciani, Alberto, Dominguez, Celia, Sherman, Leticia Toledo, Harper, Steven
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Chemical Society 2020
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7236277/
https://ncbi.nlm.nih.gov/pubmed/32435379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00594
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