Combined Peptide and Small-Molecule Approach toward Nonacidic THIQ Inhibitors of the KEAP1/NRF2 Interaction

[Image: see text] The NRF2-ARE pathway is an intrinsic mechanism of defense against oxidative stress. Inhibition of the interaction between NRF2 and its main negative regulator KEAP1 is an attractive strategy toward neuroprotective agents. We report here the identification of nonacidic tetrahydroiso...

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Pubblicato in:ACS Med Chem Lett
Autori principali: Ontoria, Jesus M., Biancofiore, Ilaria, Fezzardi, Paola, Ferrigno, Federica, Torrente, Esther, Colarusso, Stefania, Bianchi, Elisabetta, Andreini, Matteo, Patsilinakos, Alexandros, Kempf, Georg, Augustin, Martin, Steinbacher, Stefan, Summa, Vincenzo, Pacifici, Robert, Muñoz-Sanjuan, Ignacio, Park, Larry, Bresciani, Alberto, Dominguez, Celia, Sherman, Leticia Toledo, Harper, Steven
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2020
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7236277/
https://ncbi.nlm.nih.gov/pubmed/32435379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00594
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