Structure-guided approach identifies a novel class of HIV-1 ribonuclease H inhibitors: binding mode insights through magnesium complexation and site-directed mutagenesis studies

Persistent HIV infection requires lifelong treatment and among the 2.1 million new HIV infections that occur every year there is an increased rate of transmitted drug-resistant mutations. This fact requires a constant and timely effort in order to identify and develop new HIV inhibitors with innovat...

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Publicado no:Medchemcomm
Main Authors: Poongavanam, Vasanthanathan, Corona, Angela, Steinmann, Casper, Scipione, Luigi, Grandi, Nicole, Pandolfi, Fabiana, Di Santo, Roberto, Costi, Roberta, Esposito, Francesca, Tramontano, Enzo, Kongsted, Jacob
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2018
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072344/
https://ncbi.nlm.nih.gov/pubmed/30108947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7md00600d
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