The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase

The development of a series of novel 7-azabenzofurans exhibiting pan-genotype inhibition of HCV NS5B polymerase via binding to the primer grip site is presented. Many challenges, including poor oral bioavailability, high clearance, bioactivation, high human serum shift, and metabolic stability were...

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Detaylı Bibliyografya
Yayımlandı:Medchemcomm
Asıl Yazarlar: Eastman, Kyle J., Parcella, Kyle, Yeung, Kap-Sun, Grant-Young, Katharine A., Zhu, Juliang, Wang, Tao, Zhang, Zhongxing, Yin, Zhiwei, Beno, Brett R., Sheriff, Steven, Kish, Kevin, Tredup, Jeffrey, Jardel, Adam G., Halan, Vivek, Ghosh, Kaushik, Parker, Dawn, Mosure, Kathy, Fang, Hua, Wang, Ying-Kai, Lemm, Julie, Zhuo, Xiaoliang, Hanumegowda, Umesh, Rigat, Karen, Donoso, Maria, Tuttle, Maria, Zvyaga, Tatyana, Haarhoff, Zuzana, Meanwell, Nicholas A., Soars, Matthew G., Roberts, Susan B., Kadow, John F.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Royal Society of Chemistry 2017
Konular:
Chemistry
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072320/
https://ncbi.nlm.nih.gov/pubmed/30108798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6md00636a
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