Preclinical Characterization of BMS-791325, an Allosteric Inhibitor of Hepatitis C Virus NS5B Polymerase

BMS-791325 is an allosteric inhibitor that binds to thumb site 1 of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase. BMS-791325 inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 at 50% inhibitory concentrations (IC(50)) below 28 nM. In cell culture, BMS-791325 inhibi...

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Hlavní autoři: Lemm, Julie A., Liu, Mengping, Gentles, Robert G., Ding, Min, Voss, Stacey, Pelosi, Lenore A., Wang, Ying-Kai, Rigat, Karen L., Mosure, Kathleen W., Bender, John A., Knipe, Jay O., Colonno, Richard, Meanwell, Nicholas A., Kadow, John F., Santone, Kenneth S., Roberts, Susan B., Gao, Min
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2014
Témata:
Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4068470/
https://ncbi.nlm.nih.gov/pubmed/24733465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02495-13
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