Mechanism of Inhibition for BMS-791325, a Novel Non-nucleoside Inhibitor of Hepatitis C Virus NS5B Polymerase

HCV infection is an urgent global health problem that has triggered a drive to discover therapies that specifically target the virus. BMS-791325 is a novel direct antiviral agent specifically targeting HCV NS5B, an RNA-dependent RNA polymerase. Robust viral clearance of HCV was observed in infected...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Rigat, Karen L., Lu, Hao, Wang, Ying-Kai, Argyrou, Argyrides, Fanslau, Caroline, Beno, Brett, Wang, Yi, Marcinkeviciene, Jovita, Ding, Min, Gentles, Robert G., Gao, Min, Abell, Lynn M., Roberts, Susan B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246100/
https://ncbi.nlm.nih.gov/pubmed/25301950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.613653
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