Preclinical Profile and Characterization of the Hepatitis C Virus NS3 Protease Inhibitor Asunaprevir (BMS-650032)

Asunaprevir (ASV; BMS-650032) is a hepatitis C virus (HCV) NS3 protease inhibitor that has demonstrated efficacy in patients chronically infected with HCV genotype 1 when combined with alfa interferon and/or the NS5A replication complex inhibitor daclatasvir. ASV competitively binds to the NS3/4A pr...

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Hlavní autoři: McPhee, Fiona, Sheaffer, Amy K., Friborg, Jacques, Hernandez, Dennis, Falk, Paul, Zhai, Guangzhi, Levine, Steven, Chaniewski, Susan, Yu, Fei, Barry, Diana, Chen, Chaoqun, Lee, Min S., Mosure, Kathy, Sun, Li-Qiang, Sinz, Michael, Meanwell, Nicholas A., Colonno, Richard J., Knipe, Jay, Scola, Paul
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2012
Témata:
Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457370/
https://ncbi.nlm.nih.gov/pubmed/22869577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01186-12
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