The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase

The development of a series of novel 7-azabenzofurans exhibiting pan-genotype inhibition of HCV NS5B polymerase via binding to the primer grip site is presented. Many challenges, including poor oral bioavailability, high clearance, bioactivation, high human serum shift, and metabolic stability were...

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Publicat a:Medchemcomm
Autors principals: Eastman, Kyle J., Parcella, Kyle, Yeung, Kap-Sun, Grant-Young, Katharine A., Zhu, Juliang, Wang, Tao, Zhang, Zhongxing, Yin, Zhiwei, Beno, Brett R., Sheriff, Steven, Kish, Kevin, Tredup, Jeffrey, Jardel, Adam G., Halan, Vivek, Ghosh, Kaushik, Parker, Dawn, Mosure, Kathy, Fang, Hua, Wang, Ying-Kai, Lemm, Julie, Zhuo, Xiaoliang, Hanumegowda, Umesh, Rigat, Karen, Donoso, Maria, Tuttle, Maria, Zvyaga, Tatyana, Haarhoff, Zuzana, Meanwell, Nicholas A., Soars, Matthew G., Roberts, Susan B., Kadow, John F.
Format: Artigo
Idioma:Inglês
Publicat: Royal Society of Chemistry 2017
Matèries:
Chemistry
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072320/
https://ncbi.nlm.nih.gov/pubmed/30108798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6md00636a
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