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GDF15 deficiency promotes high fat diet-induced obesity in mice

Pharmacological treatment of recombinant growth differentiation factor 15 (GDF15) proteins reduces body weight in obese rodents and primates. Paradoxically, circulating GDF15 levels are increased in obesity. To investigate the role of endogenous GDF15 in obesity development, we put GDF15 knockout mi...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS One
Prif Awduron: Tran, Thanhvien, Yang, Jingping, Gardner, Jonitha, Xiong, Yumei
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072047/
https://ncbi.nlm.nih.gov/pubmed/30070999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0201584
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