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Increased susceptibility of Trpv4-Deficient Mice to Obesity and Obesity-Induced Osteoarthritis with Very High-Fat Diet
OBJECTIVE: To test the hypotheses that: 1) the transient receptor potential vanilloid 4 (TRPV4) ion channel is protective in the obesity-model of osteoarthritis (OA), resulting in more severe obesity-induced OA in Trpv4 knockout (Trpv4(−/−)) mice; and 2) loss of TRPV4 alters mesodermal stem cell dif...
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| Principais autores: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3549299/ https://ncbi.nlm.nih.gov/pubmed/23178209 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2012-202272 |
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