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Chondroprotective role of the osmotically-sensitive ion channel TRPV4: Age- and sex-dependent progression of osteoarthritis in Trpv4 deficient mice

OBJECTIVES: Mechanical loading significantly influences the physiology and pathology of articular cartilage, although the mechanisms of mechanical signal transduction are not fully understood. Transient receptor potential vanilloid 4 (TRPV4) is a calcium (Ca(++)) permeable ion channel that is highly...

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Detalhes bibliográficos
Main Authors: Clark, Andrea L., Votta, Bartholomew J., Kumar, Sanjay, Liedtke, Wolfgang, Guilak, Farshid
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3027356/
https://ncbi.nlm.nih.gov/pubmed/20583100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.27624
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