Functional Characterization of TRPV4 As an Osmotically Sensitive Ion Channel in Articular Chondrocytes

OBJECTIVE: Transient receptor potential vanilloid 4 (TRPV4) is a Ca(2+) permeable channel that can be gated by tonicity (osmolarity) and mechanical stimuli. Chondrocytes, the cells in cartilage, respond to their osmotic and mechanical environments; however, the molecular basis of this signal transdu...

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Main Authors: Phan, Mimi N., Leddy, Holly A., Votta, Bartholomew J., Kumar, Sanjay, Levy, Dana S., Lipshutz, David B., Lee, Sukhee, Liedtke, Wolfgang, Guilak, Farshid
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2846816/
https://ncbi.nlm.nih.gov/pubmed/19790068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.24799
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