CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions

The observation that BRCA1- and BRCA2-deficient cells are sensitive to poly(ADP-ribose) polymerase (PARP) inhibitors spurred their development into cancer therapies that target homologous recombination (HR) deficiency1. The cytotoxicity of PARP inhibitors depends on PARP trapping, the formation of n...

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Bibliografske podrobnosti
izdano v:Nature
Main Authors: Zimmermann, Michal, Murina, Olga, Reijns, Martin A. M., Agathanggelou, Angelo, Challis, Rachel, Tarnauskaitė, Žygimantė, Muir, Morwenna, Fluteau, Adeline, Aregger, Michael, McEwan, Andrea, Yuan, Wei, Clarke, Matthew, Lambros, Maryou B., Paneesha, Shankara, Moss, Paul, Chandrashekhar, Megha, Angers, Stephane, Moffat, Jason, Brunton, Valerie G., Hart, Traver, de Bono, Johann, Stankovic, Tatjana, Jackson, Andrew P., Durocher, Daniel
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071917/
https://ncbi.nlm.nih.gov/pubmed/29973717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0291-z
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