CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions

The observation that BRCA1- and BRCA2-deficient cells are sensitive to poly(ADP-ribose) polymerase (PARP) inhibitors spurred their development into cancer therapies that target homologous recombination (HR) deficiency1. The cytotoxicity of PARP inhibitors depends on PARP trapping, the formation of n...

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書誌詳細
出版年:Nature
主要な著者: Zimmermann, Michal, Murina, Olga, Reijns, Martin A. M., Agathanggelou, Angelo, Challis, Rachel, Tarnauskaitė, Žygimantė, Muir, Morwenna, Fluteau, Adeline, Aregger, Michael, McEwan, Andrea, Yuan, Wei, Clarke, Matthew, Lambros, Maryou B., Paneesha, Shankara, Moss, Paul, Chandrashekhar, Megha, Angers, Stephane, Moffat, Jason, Brunton, Valerie G., Hart, Traver, de Bono, Johann, Stankovic, Tatjana, Jackson, Andrew P., Durocher, Daniel
フォーマット: Artigo
言語:Inglês
出版事項: 2018
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071917/
https://ncbi.nlm.nih.gov/pubmed/29973717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0291-z
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