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Identifying chemogenetic interactions from CRISPR screens with drugZ

BACKGROUND: Chemogenetic profiling enables the identification of gene mutations that enhance or suppress the activity of chemical compounds. This knowledge provides insights into drug mechanism of action, genetic vulnerabilities, and resistance mechanisms, all of which may help stratify patient popu...

詳細記述

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書誌詳細
出版年:Genome Med
主要な著者: Colic, Medina, Wang, Gang, Zimmermann, Michal, Mascall, Keith, McLaughlin, Megan, Bertolet, Lori, Lenoir, W. Frank, Moffat, Jason, Angers, Stephane, Durocher, Daniel, Hart, Traver
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6706933/
https://ncbi.nlm.nih.gov/pubmed/31439014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-019-0665-3
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