Identifying chemogenetic interactions from CRISPR screens with drugZ

BACKGROUND: Chemogenetic profiling enables the identification of gene mutations that enhance or suppress the activity of chemical compounds. This knowledge provides insights into drug mechanism of action, genetic vulnerabilities, and resistance mechanisms, all of which may help stratify patient popu...

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Detalhes bibliográficos
Publicado no:Genome Med
Main Authors: Colic, Medina, Wang, Gang, Zimmermann, Michal, Mascall, Keith, McLaughlin, Megan, Bertolet, Lori, Lenoir, W. Frank, Moffat, Jason, Angers, Stephane, Durocher, Daniel, Hart, Traver
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6706933/
https://ncbi.nlm.nih.gov/pubmed/31439014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-019-0665-3
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