Effects of Exposure to Acetaminophen and Ibuprofen on Fetal Germ Cell Development in Both Sexes in Rodent and Human Using Multiple Experimental Systems

BACKGROUND: Analgesic exposure during pregnancy may affect aspects of fetal gonadal development that are targeted by endocrine disruptors. OBJECTIVES: We investigated whether therapeutically relevant doses of acetaminophen and ibuprofen affect germ cell (GC) development in human fetal testes/ovaries...

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Detalhes bibliográficos
Publicado no:Environ Health Perspect
Main Authors: Hurtado-Gonzalez, Pablo, Anderson, Richard A., Macdonald, Joni, van den Driesche, Sander, Kilcoyne, Karen, Jørgensen, Anne, McKinnell, Chris, Macpherson, Sheila, Sharpe, Richard M., Mitchell, Rod T.
Formato: Artigo
Idioma:Inglês
Publicado em: Environmental Health Perspectives 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071829/
https://ncbi.nlm.nih.gov/pubmed/29665328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/EHP2307
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