Triazolopyrimidines identified as reversible myeloperoxidase inhibitors

Myeloperoxidase, a mammalian peroxidase involved in the immune system as an anti-microbial first responder, can produce hypochlorous acid in response to invading pathogens. Myeloperoxidase has been implicated in several chronic pathological diseases due to the chronic production of hypochlorous acid...

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發表在:Medchemcomm
Main Authors: Duclos, Franck, Abell, Lynn M., Harden, David G., Pike, Kristen, Nowak, Kimberly, Locke, Gregory A., Duke, Gerald J., Liu, Xiaoqin, Fernando, Gayani, Shaw, Scott A., Vokits, Benjamin P., Wurtz, Nicholas R., Viet, Andrew, Valente, Meriah N., Stachura, Sylwia, Sleph, Paul, Khan, Javed A., Gao, Ji, Dongre, Ashok R., Zhao, Lei, Wexler, Ruth R., Gordon, David A., Kick, Ellen K.
格式: Artigo
語言:Inglês
出版: Royal Society of Chemistry 2017
主題:
Chemistry
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071758/
https://ncbi.nlm.nih.gov/pubmed/30108726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7md00268h
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