Potent Triazolopyridine Myeloperoxidase Inhibitors

[Image: see text] Myeloperoxidase (MPO) generates reactive oxygen species that potentially contribute to many chronic inflammatory diseases. A recently reported triazolopyrimidine MPO inhibitor was optimized to improve acid stability and remove methyl guanine methyl transferase (MGMT) activity. Mult...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Wurtz, Nicholas R., Viet, Andrew, Shaw, Scott A., Dilger, Andrew, Valente, Meriah N., Khan, Javed A., Jusuf, Sutjano, Narayanan, Rangaraj, Fernando, Gayani, Lo, Fred, Liu, Xiaoqin, Locke, Gregory A., Kopcho, Lisa, Abell, Lynn M., Sleph, Paul, Basso, Michael, Zhao, Lei, Wexler, Ruth R., Duclos, Franck, Kick, Ellen K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6295853/
https://ncbi.nlm.nih.gov/pubmed/30613322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00308
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