Potent Triazolopyridine Myeloperoxidase Inhibitors

[Image: see text] Myeloperoxidase (MPO) generates reactive oxygen species that potentially contribute to many chronic inflammatory diseases. A recently reported triazolopyrimidine MPO inhibitor was optimized to improve acid stability and remove methyl guanine methyl transferase (MGMT) activity. Mult...

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Xehetasun bibliografikoak
Argitaratua izan da:ACS Med Chem Lett
Egile Nagusiak: Wurtz, Nicholas R., Viet, Andrew, Shaw, Scott A., Dilger, Andrew, Valente, Meriah N., Khan, Javed A., Jusuf, Sutjano, Narayanan, Rangaraj, Fernando, Gayani, Lo, Fred, Liu, Xiaoqin, Locke, Gregory A., Kopcho, Lisa, Abell, Lynn M., Sleph, Paul, Basso, Michael, Zhao, Lei, Wexler, Ruth R., Duclos, Franck, Kick, Ellen K.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Chemical Society 2018
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6295853/
https://ncbi.nlm.nih.gov/pubmed/30613322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00308
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