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Direct Imaging of Drug Distribution and Target Engagement of the PARP Inhibitor Rucaparib
Poly(ADP-ribose)polymerase (PARP) inhibitors have emerged as potent antitumor drugs. Here, we describe the intrinsic fluorescence properties of the clinically approved PARP inhibitor rucaparib and its potential to directly measure drug distribution and target engagement—a critical factor for underst...
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| Publicado no: | J Nucl Med |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Society of Nuclear Medicine
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6071506/ https://ncbi.nlm.nih.gov/pubmed/29572258 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.117.205765 |
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