Direct Imaging of Drug Distribution and Target Engagement of the PARP Inhibitor Rucaparib

Poly(ADP-ribose)polymerase (PARP) inhibitors have emerged as potent antitumor drugs. Here, we describe the intrinsic fluorescence properties of the clinically approved PARP inhibitor rucaparib and its potential to directly measure drug distribution and target engagement—a critical factor for underst...

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Detaylı Bibliyografya
Yayımlandı:J Nucl Med
Asıl Yazarlar: Kossatz, Susanne, Carney, Brandon, Farley, Christopher, Weber, Wolfgang A., Drain, Charles M., Reiner, Thomas
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Society of Nuclear Medicine 2018
Konular:
Molecular Imaging
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071506/
https://ncbi.nlm.nih.gov/pubmed/29572258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.117.205765
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