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Direct Imaging of Drug Distribution and Target Engagement of the PARP Inhibitor Rucaparib
Poly(ADP-ribose)polymerase (PARP) inhibitors have emerged as potent antitumor drugs. Here, we describe the intrinsic fluorescence properties of the clinically approved PARP inhibitor rucaparib and its potential to directly measure drug distribution and target engagement—a critical factor for underst...
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| Vydáno v: | J Nucl Med |
|---|---|
| Hlavní autoři: | , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Society of Nuclear Medicine
2018
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6071506/ https://ncbi.nlm.nih.gov/pubmed/29572258 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.117.205765 |
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