Direct Imaging of Drug Distribution and Target Engagement of the PARP Inhibitor Rucaparib

Poly(ADP-ribose)polymerase (PARP) inhibitors have emerged as potent antitumor drugs. Here, we describe the intrinsic fluorescence properties of the clinically approved PARP inhibitor rucaparib and its potential to directly measure drug distribution and target engagement—a critical factor for underst...

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Bibliografiske detaljer
Udgivet i:J Nucl Med
Main Authors: Kossatz, Susanne, Carney, Brandon, Farley, Christopher, Weber, Wolfgang A., Drain, Charles M., Reiner, Thomas
Format: Artigo
Sprog:Inglês
Udgivet: Society of Nuclear Medicine 2018
Fag:
Molecular Imaging
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071506/
https://ncbi.nlm.nih.gov/pubmed/29572258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.117.205765
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