A Genome-Wide Screen of Deletion Mutants in the Filamentous Saccharomyces cerevisiae Background Identifies Ergosterol as a Direct Trigger of Macrophage Pyroptosis

Phagocytic cells such as macrophages play an important role in the host defense mechanisms mounted in response to the common human fungal pathogen Candida albicans. In vitro, C. albicans triggers macrophage NLRP3-Casp1/11-mediated pyroptosis, an inflammatory programmed cell death pathway. Here, we p...

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Detaylı Bibliyografya
Yayımlandı:mBio
Asıl Yazarlar: Koselny, Kristy, Mutlu, Nebibe, Minard, Annabel Y., Kumar, Anuj, Krysan, Damian J., Wellington, Melanie
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2018
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6069111/
https://ncbi.nlm.nih.gov/pubmed/30065091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01204-18
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