A Genome-Wide Screen of Deletion Mutants in the Filamentous Saccharomyces cerevisiae Background Identifies Ergosterol as a Direct Trigger of Macrophage Pyroptosis

Phagocytic cells such as macrophages play an important role in the host defense mechanisms mounted in response to the common human fungal pathogen Candida albicans. In vitro, C. albicans triggers macrophage NLRP3-Casp1/11-mediated pyroptosis, an inflammatory programmed cell death pathway. Here, we p...

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Pubblicato in:mBio
Autori principali: Koselny, Kristy, Mutlu, Nebibe, Minard, Annabel Y., Kumar, Anuj, Krysan, Damian J., Wellington, Melanie
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6069111/
https://ncbi.nlm.nih.gov/pubmed/30065091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01204-18
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