RNase H2, mutated in Aicardi‐Goutières syndrome, promotes LINE‐1 retrotransposition

Long INterspersed Element class 1 (LINE‐1) elements are a type of abundant retrotransposons active in mammalian genomes. An average human genome contains ~100 retrotransposition‐competent LINE‐1s, whose activity is influenced by the combined action of cellular repressors and activators. TREX1, SAMHD...

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Publicado en:EMBO J
Autores principales: Benitez‐Guijarro, Maria, Lopez‐Ruiz, Cesar, Tarnauskaitė, Žygimantė, Murina, Olga, Mian Mohammad, Mahwish, Williams, Thomas C, Fluteau, Adeline, Sanchez, Laura, Vilar‐Astasio, Raquel, Garcia‐Canadas, Marta, Cano, David, Kempen, Marie‐Jeanne HC, Sanchez‐Pozo, Antonio, Heras, Sara R, Jackson, Andrew P, Reijns, Martin AM, Garcia‐Perez, Jose L
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2018
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6068448/
https://ncbi.nlm.nih.gov/pubmed/29959219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201798506
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