RNase H2, mutated in Aicardi‐Goutières syndrome, promotes LINE‐1 retrotransposition

Long INterspersed Element class 1 (LINE‐1) elements are a type of abundant retrotransposons active in mammalian genomes. An average human genome contains ~100 retrotransposition‐competent LINE‐1s, whose activity is influenced by the combined action of cellular repressors and activators. TREX1, SAMHD...

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Publicat a:EMBO J
Autors principals: Benitez‐Guijarro, Maria, Lopez‐Ruiz, Cesar, Tarnauskaitė, Žygimantė, Murina, Olga, Mian Mohammad, Mahwish, Williams, Thomas C, Fluteau, Adeline, Sanchez, Laura, Vilar‐Astasio, Raquel, Garcia‐Canadas, Marta, Cano, David, Kempen, Marie‐Jeanne HC, Sanchez‐Pozo, Antonio, Heras, Sara R, Jackson, Andrew P, Reijns, Martin AM, Garcia‐Perez, Jose L
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2018
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6068448/
https://ncbi.nlm.nih.gov/pubmed/29959219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201798506
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