Macrophage migration inhibitory factor promotes resistance to MEK blockade in KRAS mutant colorectal cancer cells

Although MEK blockade has been highlighted as a promising antitumor drug, it has poor clinical efficacy in KRAS mutant colorectal cancer (CRC). Several feedback systems have been described in which inhibition of one intracellular pathway leads to activation of a parallel signaling pathway, thereby d...

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Dettagli Bibliografici
Pubblicato in:Mol Oncol
Autori principali: Cheon, Seul‐Ki, Kim, Hwang‐Phill, Park, Ye‐Lim, Jang, Jee‐Eun, Lim, Yoojoo, Song, Sang‐Hyun, Han, Sae‐Won, Kim, Tae‐You
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2018
Soggetti:
Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6068346/
https://ncbi.nlm.nih.gov/pubmed/29896883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12345
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