Macrophage migration inhibitory factor promotes resistance to MEK blockade in KRAS mutant colorectal cancer cells

Although MEK blockade has been highlighted as a promising antitumor drug, it has poor clinical efficacy in KRAS mutant colorectal cancer (CRC). Several feedback systems have been described in which inhibition of one intracellular pathway leads to activation of a parallel signaling pathway, thereby d...

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Bibliografiske detaljer
Udgivet i:Mol Oncol
Main Authors: Cheon, Seul‐Ki, Kim, Hwang‐Phill, Park, Ye‐Lim, Jang, Jee‐Eun, Lim, Yoojoo, Song, Sang‐Hyun, Han, Sae‐Won, Kim, Tae‐You
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2018
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6068346/
https://ncbi.nlm.nih.gov/pubmed/29896883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12345
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