Stimulator of interferon genes (STING) provides insect antiviral immunity by promoting Dredd caspase–mediated NF-κB activation

The antiviral cGMP–AMP (cGAMP)–stimulator of interferon genes (STING) pathway is well characterized in mammalian cells. However, whether this pathway also plays a role in insect antiviral immunity is unknown. In this study, we found that cGAMP is produced in silkworm (Bombyx mori) cells infected wit...

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Vydáno v:J Biol Chem
Hlavní autoři: Hua, Xiaoting, Li, Binbin, Song, Liang, Hu, Cuimei, Li, Xianyang, Wang, Dandan, Xiong, Ying, Zhao, Ping, He, Huawei, Xia, Qingyou, Wang, Fei
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2018
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6066306/
https://ncbi.nlm.nih.gov/pubmed/29875158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000194
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