NLRC5 negatively regulates the NF-κB and type I interferon signaling pathways and antiviral immunity

Stringent control of the NF-κB and type I interferon pathways is critical to effective host immune responses, yet the molecular mechanisms that negatively regulate these pathways are poorly understood. Here we show that NLRC5, a member of the NOD-like protein family, can inhibit the IKK complex and...

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Autores principales: Cui, Jun, Zhu, Liang, Xia, Xiaojun, Wang, Helen Y., Legras, Xavier, Jun, Hong, Ji, Jiabing, Shen, Pingping, Zheng, Shu, Chen, Zhijian J., Wang, Rong-Fu
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3150216/
https://ncbi.nlm.nih.gov/pubmed/20434986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.03.040
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