Reversible ubiquitination shapes NLRC5 function and modulates NF-κB activation switch

NLRC5 is an important regulator in innate immune responses. However, the ability of NLRC5 to inhibit NF-κB activation is controversial in different cell types. How dynamic modification of NLRC5 shapes NF-κB signaling remains unknown. We demonstrated that NLRC5 undergoes robust ubiquitination by TRAF...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Meng, Qingcai, Cai, Chunmei, Sun, Tingzhe, Wang, Qianliang, Xie, Weihong, Wang, Rongfu, Cui, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2015
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4674279/
https://ncbi.nlm.nih.gov/pubmed/26620909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201505091
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