Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation

Stimulator of interferon genes (STING) is a key regulator of type I interferon and pro-inflammatory responses during infection, cellular stress, and cancer. Here, we reveal a mechanism for how STING balances activation of IRF3- and NF-κB-dependent transcription and discover that acquisition of discr...

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Gepubliceerd in:Cell Rep
Hoofdauteurs: de Oliveira Mann, Carina C., Orzalli, Megan H., King, David S., Kagan, Jonathan C., Lee, Amy S.Y., Kranzusch, Philip J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7733315/
https://ncbi.nlm.nih.gov/pubmed/31018131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.03.098
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