A non-retinoid antagonist of retinol-binding protein 4 rescues phenotype in a model of Stargardt disease without inhibiting the visual cycle

A primary pathological defect in the heritable eye disorder Stargardt disease is excessive accumulation of cytotoxic lipofuscin bisretinoids in the retina. Age-dependent accumulation of lipofuscin in the retinal pigment epithelium (RPE) matches the age-dependent increase in the incidence of the atro...

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Vydáno v:J Biol Chem
Hlavní autoři: Racz, Boglarka, Varadi, Andras, Kong, Jian, Allikmets, Rando, Pearson, Paul G., Johnson, Graham, Cioffi, Christopher L., Petrukhin, Konstantin
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2018
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6065170/
https://ncbi.nlm.nih.gov/pubmed/29871924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002062
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