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The Calcium-Dependent Protease Calpain-1 Links TRPC6 Activity to Podocyte Injury
BACKGROUND: The hallmark of podocytopathies, such as FSGS, is podocyte injury resulting in proteinuria. Transient receptor potential channel C6 (TRPC6) is a calcium-conducting ion channel expressed at the slit diaphragm. TRPC6 gain-of-function mutations and glomerular TRPC6 overexpression are associ...
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| Veröffentlicht in: | J Am Soc Nephrol |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society of Nephrology
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6065075/ https://ncbi.nlm.nih.gov/pubmed/29954830 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2016111248 |
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