The Calcium-Dependent Protease Calpain-1 Links TRPC6 Activity to Podocyte Injury

BACKGROUND: The hallmark of podocytopathies, such as FSGS, is podocyte injury resulting in proteinuria. Transient receptor potential channel C6 (TRPC6) is a calcium-conducting ion channel expressed at the slit diaphragm. TRPC6 gain-of-function mutations and glomerular TRPC6 overexpression are associ...

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Bibliographic Details
Published in:J Am Soc Nephrol
Main Authors: Verheijden, Kim A.T., Sonneveld, Ramon, Bakker-van Bebber, Marinka, Wetzels, Jack F.M., van der Vlag, Johan, Nijenhuis, Tom
Format: Artigo
Language:Inglês
Published: American Society of Nephrology 2018
Subjects:
Basic Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6065075/
https://ncbi.nlm.nih.gov/pubmed/29954830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2016111248
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