TRPC6 Binds to and Activates Calpain, Independent of Its Channel Activity, and Regulates Podocyte Cytoskeleton, Cell Adhesion, and Motility

BACKGROUND: Mutations in the transient receptor potential channel 6 (TRPC6) gene are associated with an inherited form of FSGS. Despite widespread expression, patients with TRPC6 mutations do not present with any other pathologic phenotype, suggesting that this protein has a unique yet unidentified...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Farmer, Louise K., Rollason, Ruth, Whitcomb, Daniel J., Ni, Lan, Goodliff, Alexander, Lay, Abigail C., Birnbaumer, Lutz, Heesom, Kate J., Xu, Shang-Zhong, Saleem, Moin A., Welsh, Gavin I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2019
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6779362/
https://ncbi.nlm.nih.gov/pubmed/31416818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2018070729
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