TRPC6 Binds to and Activates Calpain, Independent of Its Channel Activity, and Regulates Podocyte Cytoskeleton, Cell Adhesion, and Motility

BACKGROUND: Mutations in the transient receptor potential channel 6 (TRPC6) gene are associated with an inherited form of FSGS. Despite widespread expression, patients with TRPC6 mutations do not present with any other pathologic phenotype, suggesting that this protein has a unique yet unidentified...

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Vydáno v:J Am Soc Nephrol
Hlavní autoři: Farmer, Louise K., Rollason, Ruth, Whitcomb, Daniel J., Ni, Lan, Goodliff, Alexander, Lay, Abigail C., Birnbaumer, Lutz, Heesom, Kate J., Xu, Shang-Zhong, Saleem, Moin A., Welsh, Gavin I.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Nephrology 2019
Témata:
Basic Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6779362/
https://ncbi.nlm.nih.gov/pubmed/31416818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2018070729
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