Aberrant Mitochondrial Fission Is Maladaptive in Desmin Mutation–Induced Cardiac Proteotoxicity

BACKGROUND: Desmin filament proteins interlink the contractile myofibrillar apparatus with mitochondria, nuclei and the sarcolemma. Mutations in the human desmin gene cause cardiac disease, remodeling, and heart failure but the pathophysiological mechanisms remain unknown. METHODS AND RESULTS: Cardi...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Am Heart Assoc
Egile Nagusiak: Alam, Shafiul, Abdullah, Chowdhury S., Aishwarya, Richa, Miriyala, Sumitra, Panchatcharam, Manikandan, Peretik, Jonette M., Orr, A. Wayne, James, Jeanne, Robbins, Jeffrey, Bhuiyan, Md. Shenuarin
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2018
Gaiak:
Original Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6064863/
https://ncbi.nlm.nih.gov/pubmed/29987122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.118.009289
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