Aberrant Mitochondrial Fission Is Maladaptive in Desmin Mutation–Induced Cardiac Proteotoxicity

BACKGROUND: Desmin filament proteins interlink the contractile myofibrillar apparatus with mitochondria, nuclei and the sarcolemma. Mutations in the human desmin gene cause cardiac disease, remodeling, and heart failure but the pathophysiological mechanisms remain unknown. METHODS AND RESULTS: Cardi...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Alam, Shafiul, Abdullah, Chowdhury S., Aishwarya, Richa, Miriyala, Sumitra, Panchatcharam, Manikandan, Peretik, Jonette M., Orr, A. Wayne, James, Jeanne, Robbins, Jeffrey, Bhuiyan, Md. Shenuarin
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6064863/
https://ncbi.nlm.nih.gov/pubmed/29987122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.118.009289
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