Aberrant Mitochondrial Fission Is Maladaptive in Desmin Mutation–Induced Cardiac Proteotoxicity

BACKGROUND: Desmin filament proteins interlink the contractile myofibrillar apparatus with mitochondria, nuclei and the sarcolemma. Mutations in the human desmin gene cause cardiac disease, remodeling, and heart failure but the pathophysiological mechanisms remain unknown. METHODS AND RESULTS: Cardi...

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Vydáno v:J Am Heart Assoc
Hlavní autoři: Alam, Shafiul, Abdullah, Chowdhury S., Aishwarya, Richa, Miriyala, Sumitra, Panchatcharam, Manikandan, Peretik, Jonette M., Orr, A. Wayne, James, Jeanne, Robbins, Jeffrey, Bhuiyan, Md. Shenuarin
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2018
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6064863/
https://ncbi.nlm.nih.gov/pubmed/29987122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.118.009289
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