Dysfunctional Mitochondrial Dynamic and Oxidative Phosphorylation Precedes Cardiac Dysfunction in R120G‐αB‐Crystallin‐Induced Desmin‐Related Cardiomyopathy

BACKGROUND: The mutated α‐B‐Crystallin (CryAB(R120G)) mouse model of desmin‐related myopathy (DRM) shows an age‐dependent onset of pathologic cardiac remodeling and progression of heart failure. CryAB(R120G) expression in cardiomyocytes affects the mitochondrial spatial organization within the myofi...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Alam, Shafiul, Abdullah, Chowdhury S., Aishwarya, Richa, Morshed, Mahboob, Nitu, Sadia S., Miriyala, Sumitra, Panchatcharam, Manikandan, Kevil, Christopher G., Orr, A. Wayne, Bhuiyan, Md. Shenuarin
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7763772/
https://ncbi.nlm.nih.gov/pubmed/33208022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.120.017195
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