Aberrant Mitochondrial Fission Is Maladaptive in Desmin Mutation–Induced Cardiac Proteotoxicity

BACKGROUND: Desmin filament proteins interlink the contractile myofibrillar apparatus with mitochondria, nuclei and the sarcolemma. Mutations in the human desmin gene cause cardiac disease, remodeling, and heart failure but the pathophysiological mechanisms remain unknown. METHODS AND RESULTS: Cardi...

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Dettagli Bibliografici
Pubblicato in:J Am Heart Assoc
Autori principali: Alam, Shafiul, Abdullah, Chowdhury S., Aishwarya, Richa, Miriyala, Sumitra, Panchatcharam, Manikandan, Peretik, Jonette M., Orr, A. Wayne, James, Jeanne, Robbins, Jeffrey, Bhuiyan, Md. Shenuarin
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2018
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6064863/
https://ncbi.nlm.nih.gov/pubmed/29987122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.118.009289
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